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| First Name: | Grace (Beth) | | Last Name: | Stutzmann | | Title: | Assistant Professor | | Advanced Degrees: | Ph.D | | Affiliation: | Rosalind Franklin University/The Chicago Medical School | | Department: | Department of Neuroscience | | Street Address 1: | 3333 Green Bay Road | | City: | North Chicago | | State/Province: | IL | | Zip/Postal Code: | 60064 | Country/Territory: | U.S.A. | | Phone: | (847) 578-8540 | | Fax: | (847) 578-8515 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 1 September 2009]
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View all comments by Grace (Beth) Stutzmann
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Polyglutamine Disorders (Huntington's, etc.), Aging Process, Parkinson Disease, Alzheimer Disease
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Signal transduction, Microscopy, Neurobiology, Neuropathology, Neurotransmission, Electrophysiology, A-beta PP/A-beta, Animal Models
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Research Areas:
2005-present Rosalind Franklin University of Medicine and Science/The Chicago Medical School (Department of Neuroscience) Electrophysiological, multi-photon imagining, and molecular studies examining the role of neuronal calcium signaling in normal and neurodegenerative processes, particularly in aging and early Alzheimer's disease pathogenesis.
2001-2005 University of California, Irvine (Department of Neurobiology and Behavior - Ian Parker and Frank LaFerla, PI's) In vitro whole-cell electrophysiological recording, multi-photon imaging and molecular/transgenic studies examining mechanisms of neuronal calcium signaling, and mutations related to Alzheimer's disease and neurodegenerative diseases.
1999-2000 Yale University School of Medicine (Departments of Psychiatry and Pharmacology - George Aghajanian, PI) In vitro sharp and whole cell electrophysiological recordings in cortical and hippocampal slices examing effects of serotonin and adenosine on neuronal activity in relation to psychosis and drugs of abuse.
1995-1999 New York University (W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science - Joseph E. LeDoux, Henry and Lucy Moses Professor of Science, PI) Intracellular and extracellular in vivo and in vitro electrophysiology, iontophoresis, and immunohistochemistry studies examining effects of serotonin and stress hormones on amygdala neurons.
1992-1994 Suny at Stony Brook (Department of Psychiatry - Rex Wang, PI) Electrophysiology, in vivo single unit recording, iontophoresis and behavior studies examining serotonergic and dopaminergic involvement in psychosis and drugs of abuse.
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Chakroborty S, Goussakov I, Miller MB, Stutzmann, GE. (2009) Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. Journal of Neuroscience, 29: 9458-9470. *Faculty of 1000 Recommended Reading Award
Stutzmann GE, (2008) Seeing the brain in action: how multiphoton imaging has advanced our understanding of neuronal function. Microscopy and Microanalysis, 14(6):482-91. *Best Biological Paper Award
Stutzmann GE, (2007) The pathogenesis of Alzheimer disease: Is it a lifelong ‘calciumopathy’?
The Neuroscientist, 13(5):546-59.
Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, LaFerla F (2007) Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer mouse models. Annals of the New York Academy of Science 1097:265-277.
Stutzmann GE, Smith I, Caccamo A, Oddo S, LaFerla FM, Parker I. (2006) Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult and aged Alzheimer’s disease mice. Journal of Neuroscience,
26(20) 5180-5189.
Stutzmann GE, (2005) Calcium dysregulation, IP3, and Alzheimer’s disease. The Neuroscientist, 11(2):110-5.
Stutzmann GE and Parker I. (2005) Dynamic multi-photon imaging: a live view from cells to systems. Physiology, 20:15-21.
Stutzmann GE, Caccamo A, LaFerla FM, Parker I. (2004) IP3-mediated Ca2+ signaling is exaggerated in cortical neurons from mutant presenilin-1 knock-in mice. Journal of Neuroscience, 24(2) 508-513.
Stutzmann GE, LaFerla FM, Parker I. (2003) Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. Journal of Neuroscience, 23(3):758-65.
Marchant J, Stutzmann GE, Leissring M, LaFerla F, Parker I. (2001) Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling. Nature Biotechnology, 19:645-649.
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